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治療方針研究業績 Publications

○査読付原著論文

1.       Ryo Ozaki and Yasutaka Hanada, “Microfabrication of UV-transparent fluoropolymer using high-repetition femtosecond oscillator”, Appl. Phys. A, (accepted)

2.       Shingo Shoumura, Ryo Hamano, Yasutaka Hanada, Shigeki Mayama, Kazuo Umemura “Single cell analysis of sinking diatoms studied using a homemade ‘tumbled’optical microscope system”, J. Microbiol. Methods, 168, 105804, 2020.

3.       Tomoya Naruse and Yasutaka Hanada, “Rapid, high-quality microfabrication of the thermoset polymer PDMS using laser-induced bubbles”, Opt. Express 27, 7, pp.9429-9438, 2019.

4.       Keisuke Nemoto and Yasutaka Hanada, “Etching-Assisted Ablation of the UV-Transparent Fluoropolymer CYTOP Using Various Laser Pulse Widths and Subsequent Microfluidic Applications” Micromachines, 9, 662 (2018); doi:10.3390/mi9120662

5.       Katsuya Oguri, Hiroki Mashiko, Tatsuya Ogawa, Yasutaka Hanada, Hidetoshi Nakano, and  Hideki Gotoh, “Sub-50-as isolated extreme ultraviolet continua generated by 1.6-cycle near-infrared pulse combined with double optical gating scheme”, Appl. Phys. Lett. 112, 181105 (2018)

6.       Takuma Niioka, Yasutaka Hanada, “Surface microfabrication of conventional glass using femtosecond laser for microfluidic applications” IJAT, 11, 6 878-882 (2017)

7.       Jian Xu, Hiroyuki Kawano, Weiwei Liu, Yasutaka Hanada, Peixiang Lu, Atsushi Miyawaki, Katsumi Midorikawa and Koji Sugioka,”Controllable alignment of elongated microorganisms in 3D microspace using electrofluidic devices manufactured by hybrid femtosecond laser microfabrication”, Microsystems & Nanoengineering (2017) 3, 16078; doi:10.1038/micronano.2016.78

8.       Yasutaka Hanada, Tatsuya Ogawa, Kazuhiko Koike and Koji Sugioka, “Making the invisible visible: a microfluidic chip using a low refractive index polymer”, Lab Chip, 16, pp.2481-2486, 2016.

9.       Tatsuya Ogawa, Yasutaka Hanada, “Microfabrication of the UV transparent polymer CYTOP using a conventional pulsed green laser” Appl. Phys. A, 122, pp. 156-161, 2016.

10.     Yasutaka Hanada, Keisuke Nemoto, Toshiro Ono, “Biochip for single cell analysis using laser microfabrication”, J. Med. Devices, 10(2), 020934, 2016. doi: 10.1115/1.4033166.

11.     Nobuaki Ishikawa, Yasutaka Hanada, Ikuko Ishikawa, Koji Sugioka & Katsumi Midorikawa, “Femtosecond laser fabricated biochip for studying symbiosis between Phormidium and seedling root” Appl. Phys. B, 119, pp. 503-508, 2015.

12.     Kazuo Umemura, Yusuke Sadoya, Kazuki Nagao, Ryota Oikawa, Yasutaka Hanada, Koji Sugioka, Shigeki Mayama, ”Single cell analysis using a glass microchamber for studying movement fluctuations of Navicula pavillardii and Seminavis robusta diatom cells”, Micron 77, pp.41-43, 2015.

13.     Koji SugiokaJian XuDong WuYasutaka HanadaZhongke WangYa ChengKatsumi MidorikawaFemtosecond laser 3D micromachining: a powerful tool for the fabrication of microfluidic, optofluidic, and electrofluidic devices based on glass”, Lab Chip, 14, pp.3447-3458, 2014.

14.     Jian Xu, Dong Wu, Yasutaka Hanada, Chi Chen, Sizhu Wu, Ya Cheng, Koji Sugioka and Katsumi Midorikawa, "Electrofluidics fabricated by space-selective metallization in glass microfluidic structures using femtosecond laser direct writing", Lab Chip, 13, pp.4608-4616, 2013. 

15.     Sizhu Wu, Dong Wu, Jian Xu, Yasutaka Hanada, Ryo Suganuma, Haiyu Wang, Testuya Makimura, Koji Sugioka, and Katsumi Midorikawa, "Characterization and mechanism of glass microwelding by double-pulse ultrafast laser irradiation", Opt. Express 20, 27, pp.28893-288905, 2012.

16.     Yasutaka Hanada, Koji Sugioka, Katsumi Midorikawa, “Highly sensitive optofluidic chips for biochemical liquid assay fabricated by 3D femtosecond laser micromachining followed by polymer coating”, Lab Chip, 19, pp.3688-3693, 2012

17.     Yasutaka Hanada, Koji Sugioka, Ikuko Shihira-Ishikawa, Hiroyuki Kawano, Atsushi Miyawaki, Katsumi Midorikawa, “3D microchips with integrated functional microelements fabricated by a femtosecond laser for studying the gliding mechanism of cyanobacteria”, Lab Chip, 11, pp.2109-2115, 2011.

18.     Yasutaka Hanada, Koji Sugioka, Katsumi Midorikawa, “UV waveguides light fabricated in fluoropolymer CYTOP by femtosecond laser direct writing”, Opt. Express 18, 2, pp.446-450, 2010.

19.     Yasutaka Hanada, Koji Sugioka, Hiroyuki Kawano, Takayoshi Tsuchimoto, Iwao Miyamoto, Atsushi Miyawaki, Katsumi Midorikawa, “Selective cell culture on UV transparent polymer by F2 laser surface modification”, Appl. Sur. Sci., 255, pp.9885-9888, 2009.

20.     Yasutaka Hanada, Koji Sugioka, Hiroyuki Kawano, Ikuko Shihira Ishikawa, Atsushi Miyawaki, Katsumi Midorikawa, “Nano-aquarium with microfludics structure for dynamic analysis of Cryptomonas and Phormidium fabricated by femtosecond laser direct writing of photostructurable glass”, Appl. Sur. Sci., 255, pp.9893-9897, 2009.

21.     Yasutaka Hanada, Koji Sugioka, Hiroyuki Kawano, Ikuko Shihira Ishikawa, Atsushi Miyawaki, Katsumi Midorikawa, “Nano-aquarium for dynamic observation of living cells fabricated by femtosecond laser direct writing of photostructurable glass”, Biomed. Microdevices, 10, 3, pp. 403-410, 2008.

22.     Y. Hanada, K. Sugioka, K. Midorikawa, “Selective metallization of photostructurable glass by femtosecond laser direct writing for biochip application”, Appl. Phys. A88, pp.699-704, 2007.

23.     Yasutaka Hanada, Koji Sugioka, Iwao Miyamoto, Katsumi Midorikawa, “Colour marking of transparent materials by laser-induced plasma-assisted ablation (LIPAA)”, J. Phys. Conference series 59, pp.687-690, 2007.

24.     Yasutaka Hanada, Koji Sugioka, Kotaro Obata, Serge V. Garnov, Iwao Miyamoto and Katsumi Midorikawa, “Transient electron excitation in laser-induced plasma-assisted ablation (LIPAA) of transparent materials” J. Appl. Phys., 99, 043301, pp.043301-1-043301-6, 2006.

25.     Yasutaka Hanada, Koji Sugioka, Iwao Miyamoto, Katsumi Midorikawa, “Double-pulse irradiation by laser-induced plasma-assisted ablation (LIPAA) and mechanisms study”, Appl. Surf. Sci., 248, pp.276-280, 2005.

26.     Y. Hanada, K. Sugioka, H. Takase, H. Takai, I. Miyamoto, K Midorikawa, “Selective metallization of polyimide by laser-induced plasma-assisted ablation (LIPAA)”, Appl. Phys. A80, pp.111-115, 2005.

27.     Y. Hanada, K. Sugioka, Y. Gomi, H. Yamaoka, M. Otsuki, I. Miyamoto, K. Midorikawa, “Development of practical system for laser-induced plasma-assisted ablation (LIPAA) for micromachining of glass materials”, Appl. Phys., A79, pp.1001-1003, 2004.

28.     Yasutaka Hanada, Tomohito Imamura, Koichi Toyoda, “Volumue absorption effect for micro drilling of semi-transparent materials”, Jpn. J. Appl. Phys., 41, Suppl. 41-1, pp.90-95, 2002.

29.     花田修賢, 杉岡幸次, 緑川克美, “レーザー生成プラズマ支援アブレーション(LIPAA)による透明材料の微細加工に関する研究”, レーザー加工学会誌, 15, 1, pp.50-55, 2008.

30.     花田修賢, 杉岡幸次, 高瀬史裕, 宮本岩男, 高井裕司, 緑川克美, “レーザー生成プラズマ支援アブレーション(LIPAA)によるサファイアの加工, 高温学会誌, 30, 2, pp.105-110, 2004.

31.     Koji Sugioka, Yasutaka Hanada, Katsumi Midorikawa, “3D integration of  microcomponents in a single glass chip by femtosecond laser direct writing for biochemical analysis” Appl. Surf. Sci., 253, pp.6595-6598, 2007.

32.     Z. Wang, K. Sugioka, Y. Hanada, K. Midorikawa, “Optical waveguide fabrication and integration with a micro-mirror inside photosensitive glass by femtosecond laser direct writing”, Appl. Phys. A88, pp.699-704, 2007.

33.     Carsten WOCHNOWSKI, Ya CHENG, Yasutaka HANADA, Krassimira METEVA, Simeon METEV, Koji SUGIOKA, Gerd SEPOLD, Frank VOLLERTSEN, Katsumi MIDORIKAWA, “Fs-laser-induced Fabrication of Polymeric Optical and Fluidic ”, JLMN, 1, 3. pp.195-200, 2006.

34. C. Wochnowski, Y. Hanada, Y. Cheng, S. Metev, F. Vollertsen, K. Sugioka, K. Midorikawa, “Femtosecond-laser-assisted wet chemical etching of polymer materials”, J. Appl. Polym. Sci., 100, 2, pp.1229-1238, 2006.

○招待講演

1.       花田修賢, “低屈折率フッ素ポリマーのレーザー加工技術およびそのバイオ応用”, 学振フッ素化学155委員会, 京都, 1月(2020

2.       Yasutaka Hanada, “Microfluidic fabrication of polymer materials using laser-induced bubbleThe 8th International Congress on Laser Advanced Materials (LAMP2019), Hiroshima, June (2019)

3.       Yasutaka Hanada, “Microfabrication of UV-transparent polymer CYTOP using various lasers for biochip applications” International Symposium on SSS Laser Processing (3S-LP), Yokohama, Feb. (2019)

4.       花田修賢, “低屈折率フッ素ポリマーを用いた超短パルスレーザーによる3次元バイオチップデバイス作製およびその応用”, 41回フッ素化学討論会, 弘前, 10月(2018.

5.       花田修賢,“フェムト秒レーザー3次元加工を用いたバイオチップ作製およびその応用”, 2018年度精密工学会秋季大会シンポジウム, 函館, 9月(2018.

6.       Yasutaka Hanada, “3D biochip fabrication of fluoric polymer CYTOP for clear microscopic observation at the fluid boundary” Progress on Ultrafast Laser Modifications of Materials (PULMM) 2018, Telluride, USA, Jun. (2018).

7.       花田修賢, “超短パルスレーザを用いた機能性ポリマーの3次元バイオチップデバイス作製”, 89回レーザ加工学会, 大阪, 5 (2018).

8.       Yasutaka Hanada, “3D microfluidic fabrication using a low refractive index polymer for clear microscopic observation at the fluid boundary”, SPIE Photonics WEST 2018, San Francisco, USA, Jan. (2018).

9.       Yasutaka Hanada, “Fabrication of glass–based biochip utilizing ultrashort pulse laser and its application”, International Symposium on Micro-Nano Mechatronics and Human Science MHS2017, Nagoya, Dec. (2017)

10.  花田 修賢, “フェムト秒レーザーによるバイオ応用マイクロチップの作製”, 10 バイオナノシステムズ研究会, 神戸, 6月(2017

11.  花田 修賢, “細胞の動態観察を目的とした超短パルスレーザー3次元バイオチップ作製”, 平成28年度 第1 ガラス科学技術研究会講演, 東京, 7月(2016

12.  花田修賢, “流路内の鮮明な細胞観察を可能にする3次元バイオチップ作製”, 84回レーザー加工学会, 名古屋, 1月 (2016

13.    花田修賢, 石川 依久子, 杉岡 幸次, “細胞の詳細観察を可能にするフェムト秒レーザーを用いたバイオチップ作製”, レーザー学会学術講演会第35回年次大会, 品川, 1 (2015)

14.    Yasutaka Hanada, Koji Sugioka, “Cell observation in functional biochips fabricated by femtosecond laser direct writing”, International Union of Materials Research Societies- The IUMRS International Conference in Asia 2014 IUMRS-ICA, Fukuoka, Aug. (2014)

15.    花田修賢, 杉岡幸次, “フェムト秒レーザーを用いたバイオチップ作製およびその応用”, 74回応用物理学会学術講演会シンポジウム, 京都, 9 (2013)

16.    花田修賢, "様々なレーザーを用いた透明材料微細加工技術の開発-マイクロチップ内で観る水棲微生物-", 微細加工・計測研究会弘前産官学連携フォーラム, 弘前, 2, (2012).

17.    Y.Hanada, K. Sugioka and K. Midorikawa, "Highly sensitive concentration analysis of fluids using optofluidic chip fabricated by femtosecond laser direct writing followed by low refractive index polymer", Optofluidics, Suzhou, China, Sep. (2012).

18.    Yasutaka Hanada, Koji Sugioka, Hiroyuki Kawano, Ikuko Ishikawa, Atsushi Miyawaki, Katsumi Midorikawa, “Integrataed nano-aquarium fabricated by femtosecond laser for mechanism study of cyanobacteria’s gliding, International Symposium on Optomechatronic Technologies (ISOT), Hong Kong, China, Nov. (2011).

19.    Y. Hanada, K. Sugioka, H. Kawano, I. Ishikawa, M. Iida, H. Takai, A. Miyawaki, K. Midorikawa, “Nano-aquarium integrated with functional microcomponents in photostructurable glass by femtosecond laser micro processing for microorganism analysis, Advanced Laser Technologies (ALT09), Antalya, Turkey, Sep. (2009).

20.    花田修賢, 杉岡幸次, 河野弘幸, 石川依久子, 宮脇敦史, 緑川克美, “フェムト秒レーザー加工によるナノ水族館作製-ナノ水族館内でみる水棲微生物-”, 71回レーザ加工学会, 東京, 12 (2008).

21.    Y. Hanada, K. Sugioka, H. Kawano, I. Ishikawa, A. Miyawaki, K. Midorikawa, “Nano-aquarium with microfluidics structures fabricated by femtosecond laser direct writing for dynamic microorganism analysis”, Photonics and Optoelectronics Meetings (POEM2008), Wuhan, China, Nov. (2008).

22.    Y. Hanada, K. Sugioka, H. Kawano, I. Ishikawa, A. Miyawaki, K. Midorikawa, “Nano-aquarium for dynamic observation of aquatic microorganisms fabricated by femtosecond laser direct writing of photostructurable glass”, SPIE Photonics WEST 2008, San Jose, USA, Jan. (2008).

23.    Y. Hanada, K. Sugioka, H. Kawano, I. Ishikawa, A. Miyawaki, K. Midorikawa,Nano-aquarium fabrication by femtosecond laser direct writing for microscopic observation of aquatic microorganisms”, The 6th Asia Pacific Laser Symposium (APLS2008), Nagoya, Japan, Jan. (2008).

24.    Y. Hanada, K. Sugioka, H. Kawano, I. Ishikawa, A. Miyawaki, K. Midorikawa,Nano-aquarium for dynamic observation of aquatic microorganisms fabricated by femtosecond laser direct writing”, SPIE/COS Photonics Asia, Beijing, China, Nov. (2007).

25.    花田修賢, 杉岡幸次, 小幡幸太郎, 緑川克美,極短波長・極短パルスレーザーによるマイクロチップデバイスの作製およびその応用, 53回応用物理学関係連合講演会シンポジウム, 京都, 8 (2006).

26.    K. Sugioka, Y. Hanada, H. Kawano, I. Ishikawa, A. Miyawaki, K. Midorikawa, “Fabrication of nano-aquarium for dynamic analysis microorganisms by femtosecond laser direct writing”, Advanced Laser Technologies (ALT08), Siofok, Hungary, Sep. (2008).

27.    K. Sugioka, Y. Hanada, K. Midorikawa, “3D microchips fabricated by femtosecond laser for biomedical applications”, International Symposium on Optomechatronic Technologies (ISOT), San Diego, USA, Nov. (2008).

28.    K. Sugioka, Y. Hanada, K. Midorikawa, “Laser-induced plasma-assisted ablation (LIPAA): fundamentals and industrial applications”, SPIE High Power Laser Ablation, New Mexico, USA, May. (2006).

29.    Koji Sugioka, Yasutaka Hanada, I. Miyamoto, K. Midorikawa, “LIPAA technique and its possible impact on micro-electronics” SPIE Photonic West 2005, San Jose, USA, Jan. (2005).

受賞

1.平成165The 5th International Symposium on Laser Precision Microfabrication (LPM2004) student paper award (oral), Micromachining of transparent materials by Lase-Induced Plasma-Assisted Ablation (LIPAA), Yasutaka Hanada

2.平成181Photonics West 2006 Laser and Applications in Science and Engineering Best Student poster presentation, "Mechanism study of laser-induced plasma-assisted ablation(LIPAA)", Yasutaka Hanada

3.平成208 電気学会優秀論文発表賞, フェムト秒レーザーを用いたバイオチップデバイスの作製およびその応用, 花田修賢

4.平成2311International Symposium On Optomechatronic Technology (ISOT2011) Innovation in optomechatronic research award, "Integrated Nanoaquariums Fabricated by Femtosecond Laser for Mechanism Study of Cyanobacteria's Gliding", Yasutaka Hanada, Koji Sugioka, Hiroyuki Kawano, Ikuko Ishikawa, Atsushi Miyawaki and Katsumi Midroikawa

5.平成249The 2nd International Conference on Optofluidics 2012 The best paper awards, "High sensitive concentration analysis of fluids using optofluidic chip fabricated by femtosecond laser direct writing followed by low refractive index polymer", Y. Hanada, K. Sugioka, K. Midorikawa


特許

1.       花田修賢, 杉岡幸次, 緑川克美, “金属配線形成方法”, (特許出願番号2006-214473特許公開番号2008-41938)

2.       花田修賢, 杉岡幸次, 緑川克美, “細胞培養基板、その製造方法、細胞培養方法”, (特許出願番号2008-239786特許公開番号2010-68755)

3.       花田修賢,“透明材料の加工方法”, 特願2018-000508